Vysis® LSI® BCR/ABL Dual Color, Dual Fusion Translocation Probe
Product Description
| Probe Name | Probe Location | Fluorophore |
| Vysis LSI ASS-ABL | 9q34 | SpectrumOrange TM |
| Vysis LSI BCR | 22q11.2 | SpectrumGreen TM |
The LSI BCR/ABL Dual Color, Dual Fusion Translocation Probe is a mixture of the LSI BCR probe labeled with SpectrumGreen and the LSI ABL probe labeled with SpectrumOrange. The spanning ABL probe has a genomic target of approximately 650 kb extending from an area centromeric of the argininosuccinate synthetase gene (ASS) to well telomeric of the last ABL exon. The BCR probe target spans a genomic distance of about 1.5 Mb. The BCR probe begins within the variable segments of the immunoglobulin lambda light chain locus (IGLV), extends along chromosome 22 through the BCR gene, and ends at a point approximately 900 kb telomeric of BCR. A region of about 300 kb containing low-copy number repeats has been eliminated from the probe which introduces a gap in the coverage of the probe target. Both probes span their respective breakpoints.
Probe Map
Results of Hybridization
A normal nucleus will exhibit two orange, two green (2O2G) signal pattern.
LSI BCR/ABL Dual Color, Dual Fusion Translocation Probe hybridized to an abnormal nucleus. One orange, one green and two orange/green fusion signals are observed (1O1G2F).
Analyte Specific Reagent.
Analytical and performance characteristics are not established.
Analytical and performance characteristics are not established.
