Vysis TelVysion Probes
Telomeres are DNA-protein complexes that cap the ends of eukaryotic chromosomes. Every telomere contains 3 to 20 kb of tandem TTAGGG repeats. The telomere associated repeats (TAR), also known as the subtelomeric repeats, are immediately proximal to the TTAGGG repeats. They contain regions of shared homology between subsets of certain chromosomes.
Each TelVysion targeted site is a unique, chromosome specific DNA located approximately 100 to 300 kb from the chromosome end.
Schematic of the make-up of human chromosome telomeric regions. Diagram courtesy of C.
Lese and D. Ledbetter, University of Chicago.
In the context of constitutional chromosome analysis, the most distal region of unique DNA on a chromosome arm commonly is referred to as the "subtelomere." Subtelomeres are known to contain a high concentration of genes as compared to other chromosome regions.Yet, subtelomere abnormalities can be difficult, if not impossible, to detect by routine G-band analysis because subtelomeres stain negative (light).
Ordering Information
| Product Description | Locus | Quantity | Abbott Order # | Additional Information |
|---|---|---|---|---|
| TelVysion 1p SpectrumGreen | CEB108/T7 | 5 µL | 05J03-001 |
|
| TelVysion 2p SpectrumGreen | VIJyRM2052 | 5 µL | 05J03-002 |
|
| TelVysion 3p SpectrumGreen | D3S4559 | 5 µL | 05J03-003 |
|
| TelVysion 4p SpectrumGreen | GS10K2/T7; 4p02 | 5 µL | 05J03-004 |
|
| TelVysion 5p SpectrumGreen | C84c11/T3 | 5 µL | 05J03-005 |
|
| TelVysion 6p SpectrumGreen | 6PTEL48 | 5 µL | 05J03-006 |
|
| TelVysion 7p SpectrumGreen | VIJyRM2185 | 5 µL | 05J03-007 |
|
| TelVysion 8p SpectrumGreen | D8S504 | 5 µL | 05J03-008 |
|
| TelVysion 9p SpectrumGreen | 305J7-T7 | 5 µL | 05J03-009 |
|
| TelVysion 10p SpectrumGreen | 10pTEL006 | 5 µL | 05J03-010 |
|
| TelVysion 11p SpectrumGreen | D11S2071 | 5 µL | 05J03-011 |
|
| TelVysion 12p SpectrumGreen | 8M16/SP6 | 5 µL | 05J03-012 |
|
| TelVysion 16p SpectrumGreen | 16pTEL05 | 5 µL | 05J03-016 |
|
| TelVysion 17p SpectrumGreen | 282M16/SP6 | 5 µL | 05J03-017 |
|
| TelVysion 18p SpectrumGreen | D18S552 | 5 µL | 05J03-018 |
|
| TelVysion 19p SpectrumGreen | 129F16/SP6 | 5 µL | 05J03-019 |
|
| TelVysion 20p SpectrumGreen | 20pTEL18 | 5 µL | 05J03-020 |
|
| TelVysion 1q SpectrumOrange | VIJyRM2123, 1QTEL10 (D1S3738, GDB: 9043912) | 5 µL | 05J04-001 |
|
| TelVysion 2q SpectrumOrange | D2S447 | 5 µL | 05J04-002 |
|
| TelVysion 3q SpectrumOrange | D3S4560 | 5 µL | 05J04-003 |
|
| TelVysion 4q SpectrumOrange | D4S2930 | 5 µL | 05J04-004 |
|
| TelVysion 5q SpectrumOrange | D5S2907 | 5 µL | 05J04-005 |
|
| Telvysion 6q SpectrumOrange | VIJyRM2158 | 5μl | 05J04-006 |
|
| TelVysion 7q SpectrumOrange | VIJyRM2000 | 5 µL | 05J04-007 |
|
| TelVysion 8q SpectrumOrange | VIJyRM2053 | 5 µL | 05J04-008 |
|
| TelVysion 9q SpectrumOrange | D9S325 | 5 µL | 05J04-009 |
|
| TelVysion 10q SpectrumOrange | D10S2290 | 5 µL | 05J04-010 |
|
| TelVysion 11q SpectrumOrange | D11S1037 | 5 µL | 05J04-011 |
|
| TelVysion 12q SpectrumOrange | VIJyRM2196 | 5 µL | 05J04-012 |
|
| TelVysion 13q SpectrumOrange | D13S327 | 5 µL | 05J04-013 |
|
| TelVysion 14q SpectrumOrange | D14S1420 | 5 µL | 05J04-014 |
|
| TelVysion 15q SpectrumOrange | D15S936 | 5 µL | 05J04-015 |
|
| TelVysion 16q SpectrumOrange | 16qTEL013 | 5 µL | 05J04-016 |
|
| TelVysion 17q SpectrumOrange | D17S928 | 5 µL | 05J04-017 |
|
| TelVysion 18q SpectrumOrange | VIJyRM2050 | 5 µL | 05J04-018 |
|
| TelVysion 19q SpectrumOrange | D19S238E | 5 µL | 05J04-019 |
|
| TelVysion 20q SpectrumOrange | 20QTEL14 | 5 µL | 05J04-020 |
|
| TelVysion 21q SpectrumOrange | VIJyRM2029 | 5 µL | 05J04-021 |
|
| TelVysion 22q SpectrumOrange | MS607;ACR | 5 µL | 05J04-022 |
|
